All Publications

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  1. Tiffany Y. Kim, Anne L. Schafer. Chapter 59 Bariatric surgery, vitamin D, and bone loss. Feldman and Pike's Vitamin D. 2024 Jan 1; 161-184. View in PubMed
  2. Wu PH, Joseph G, Saeed I, Pirmoazen AM, Kenny K, Kim TY, Schafer AL, Schwartz AV, Li X, Link TM, Kazakia GJ. Bone marrow adiposity alterations in type 2 diabetes are sex-specific and associated with serum lipid levels. J Bone Miner Res. 2023 Oct 30. View in PubMed
  3. Eileen H Koh, Susan K Ewing, Sigurdur Sigurdsson, Vilmundar Guðnason, Trisha F Hue, Eric Vittinghoff, Mone Zaidi, Clifford J Rosen, Claes Ohlsson, Louise Grahnemo, Åsa Tivesten, Ann V Schwartz, Anne L Schafer. FRI675 Higher FSH Level Is Associated With Increased Risk Of Incident Hip Fracture In Older Adults, Independent Of Sex Hormone Levels. Journal of the Endocrine Society. 2023 Oct 5; 7(Supplement_1):bvad114.443. View in PubMed
  4. Giustina A, di Filippo L, Facciorusso A, Adler RA, Binkley N, Bollerslev J, Bouillon R, Casanueva FF, Cavestro GM, Chakhtoura M, Conte C, Donini LM, Ebeling PR, Fassio A, Frara S, Gagnon C, Latella G, Marcocci C, Mechanick JI, Minisola S, Rizzoli R, Santini F, Shaker JL, Sempos C, Ulivieri FM, Virtanen JK, Napoli N, Schafer AL, Bilezikian JP. Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis. Rev Endocr Metab Disord. 2023 Sep 04. View in PubMed
  5. Link TM, Schafer AL. Bariatric Surgery Negatively Impacts Bone Health in Adolescents. Radiology. 2023 06; 307(5):e231260. View in PubMed
  6. Wu KC, Cao S, Weaver CM, King NJ, Patel S, Kim TY, Black DM, Kingman H, Shafer MM, Rogers SJ, Stewart L, Carter JT, Posselt AM, Schafer AL. Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status. J Clin Endocrinol Metab. 2023 01 17; 108(2):351-360. View in PubMed
  7. Teng PF, Chiang JM, Schafer AL, Sukerkar PA, Keaveny TM, Bikle D. Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT). Osteoporos Int. 2023 Mar; 34(3):551-561. View in PubMed
  8. Lee JY, Fan B, Montenegro G, Long RK, Sanda S, Capodanno G, Schafer AL, Burghardt AJ, Rosenthal SM, Fung EB. Interpretation of Bone Mineral Density Z-Scores by Dual-Energy X-Ray Absorptiometry in Transgender and Gender Diverse Youth Prior to Gender-Affirming Medical Therapy. J Clin Densitom. 2022 Oct-Dec; 25(4):559-568. View in PubMed
  9. Kim TY, Schwartz AV, Li X, Xu K, Kazakia GJ, Grunfeld C, Nissenson RA, Shoback DM, Schafer AL. Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery. Bone Rep. 2022 Dec; 17:101596. View in PubMed
  10. Babey ME, Ewing SK, Strotmeyer ES, Napoli N, Schafer AL, Vittinghoff E, Gundberg CM, Schwartz AV. No Evidence of Association Between Undercarboxylated Osteocalcin and Incident Type 2 Diabetes. J Bone Miner Res. 2022 05; 37(5):876-884. View in PubMed
  11. Sadoughi S, Pasco C, Joseph GB, Wu PH, Schafer AL, Kazakia GJ. Cortical Bone Loss Following Gastric Bypass Surgery Is Not Primarily Endocortical. J Bone Miner Res. 2022 04; 37(4):753-763. View in PubMed
  12. Woods GN, Ewing SK, Schafer AL, Gudnason V, Sigurdsson S, Lang T, Hue TF, Kado DM, Vittinghoff E, Rosen C, Li X, Schwartz AV. Saturated and Unsaturated Bone Marrow Lipids Have Distinct Effects on Bone Density and Fracture Risk in Older Adults. J Bone Miner Res. 2022 04; 37(4):700-710. View in PubMed
  13. Wu KC, Cao S, Weaver CM, King NJ, Patel S, Kingman H, Sellmeyer DE, McCauley K, Li D, Lynch SV, Kim TY, Black DM, Shafer MM, Özçam M, Lin DL, Rogers SJ, Stewart L, Carter JT, Posselt AM, Schafer AL. Prebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2022 03 24; 107(4):1053-1064. View in PubMed
  14. Black DM, Reid IR, Napoli N, Ewing SK, Shiraki M, Nakamura T, Takeuchi Y, Schafer AL, Kim TY, Cauley JA. The Interaction of Acute-Phase Reaction and Efficacy for Osteoporosis After Zoledronic Acid: HORIZON Pivotal Fracture Trial. J Bone Miner Res. 2022 01; 37(1):21-28. View in PubMed
  15. Wu KC, Ewing SK, Li X, Sigurðsson S, Guðnason V, Kado DM, Hue TF, Woods GN, Veldhuis-Vlug AG, Vittinghoff E, Zaidi M, Rosen CJ, Lang T, Kim TY, Schwartz AV, Schafer AL. FSH Level and Changes in Bone Mass and Body Composition in Older Women and Men. J Clin Endocrinol Metab. 2021 09 27; 106(10):2876-2889. View in PubMed
  16. Schafer AL, Shoback DM. A Distinction Without a Difference-Does It Matter Whether Fractures Are Nontraumatic or Traumatic? JAMA Intern Med. 2021 08 01; 181(8):1063-1064. View in PubMed
  17. Karin C. Wu, Elaine W. Yu, Anne L. Schafer. Chapter 51 Skeletal health after bariatric surgery. . 2021 Jan 1; 1261-1280. View in PubMed
  18. Veldhuis-Vlug AG, Woods GN, Sigurdsson S, Ewing SK, Le PT, Hue TF, Vittinghoff E, Xu K, Gudnason V, Sigurdsson G, Kado DM, Eiriksdottir G, Harris T, Schafer AL, Li X, Zaidi M, Rosen CJ, Schwartz AV. Serum FSH Is Associated With BMD, Bone Marrow Adiposity, and Body Composition in the AGES-Reykjavik Study of Older Adults. J Clin Endocrinol Metab. 2021 03 08; 106(3):e1156-e1169. View in PubMed
  19. Wu PH, Gupta T, Chang H, Petrenko D, Schafer A, Kazakia G. Soft tissue variations influence HR-pQCT density measurements in a spatially dependent manner. Bone. 2020 09; 138:115505. View in PubMed
  20. Kim TY, Shoback DM, Black DM, Rogers SJ, Stewart L, Carter JT, Posselt AM, King NJ, Schafer AL. Increases in PYY and uncoupling of bone turnover are associated with loss of bone mass after gastric bypass surgery. Bone. 2020 02; 131:115115. View in PubMed
  21. Hindi SM, Vittinghoff E, Schafer AL, Silverman S, Bauer DC. Commercial Laboratory Reproducibility of Serum CTX in Clinical Practice. JBMR Plus. 2019 Oct; 3(10):e10225. View in PubMed
  22. Lyo V, Schafer AL, Stewart L. Roux-en-Y gastric bypass is a safe and effective option that improves major Co-Morbidities associated with obesity in an older, veteran population. Am J Surg. 2019 10; 218(4):684-688. View in PubMed
  23. Alliston T, Schafer A. Bone Quality Sleuths: Uncovering Tissue-Level Mechanisms of Bone Fragility in Human Type 2 Diabetes. J Bone Miner Res. 2019 07; 34(7):1189-1190. View in PubMed
  24. Niu A, Carpenter TO, Grams JM, Bozorgmehri S, Tommasini SM, Schafer AL, Canales BK. High dose vitamin D supplementation does not rescue bone loss following Roux-en-Y gastric bypass in female rats. Bone. 2019 10; 127:172-180. View in PubMed
  25. Zahner GJ, Ramirez JL, Spaulding KA, Khetani SA, Gasper WJ, Grunfeld C, Hills NK, Schafer AL, Grenon SM. Leptinemia is Associated With Peripheral Artery Disease. J Surg Res. 2019 06; 238:48-56. View in PubMed
  26. Alba DL, Wu L, Cawthon PM, Mulligan K, Lang T, Patel S, King NJ, Carter JT, Rogers SJ, Posselt AM, Stewart L, Shoback DM, Schafer AL. Changes in Lean Mass, Absolute and Relative Muscle Strength, and Physical Performance After Gastric Bypass Surgery. J Clin Endocrinol Metab. 2019 03 01; 104(3):711-720. View in PubMed
  27. Hicks GE, Shardell MD, Miller RR, Eastlack M, Orwig DL, Goodpaster BH, Chomentowski PJ, Hochberg MC, Rathbun AM, Cauley JA, Harris T, Satterfield S, Schafer AL, Magaziner J. Trunk Muscle Composition 2 Months After Hip Fracture: Findings From the Baltimore Hip Studies. Arch Phys Med Rehabil. 2019 09; 100(9):1663-1671. View in PubMed
  28. Kim TY, Bauer DC, McNabb BL, Schafer AL, Cosman F, Black DM, Eastell R. Comparison of BMD Changes and Bone Formation Marker Levels 3 Years After Bisphosphonate Discontinuation: FLEX and HORIZON-PFT Extension I Trials. J Bone Miner Res. 2019 05; 34(5):810-816. View in PubMed
  29. Ramirez JL, Khetani SA, Zahner GJ, Spaulding KA, Schaller MS, Gasper WJ, Hills NK, Schafer AL, Grenon SM. Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease. J Vasc Surg. 2019 02; 69(2):497-506. View in PubMed
  30. Anne L. Schafer, Dolores M. Shoback. Hypocalcemia. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 2018 Sep 28; 646-653. View in PubMed
  31. Alba DL, Farooq JA, Lin MYC, Schafer AL, Shepherd J, Koliwad SK. Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans. J Clin Endocrinol Metab. 2018 09 01; 103(9):3194-3204. View in PubMed
  32. Joel L. Ramirez, Sukaynah A. Khetani, Greg J. Zahner, Melinda S. Schaller, Warren J. Gasper, Nancy K. Hills, Anne L. Schafer, S. Marlene Grenon. PC128. Serum Resistin Is Associated With Impaired Endothelial Function and Poor Outcomes in Patients With Peripheral Artery Disease. Journal of Vascular Surgery. 2018 Jun 1; 67(6):e208-e209. View in PubMed
  33. Joel L. Ramirez, Sukaynah A. Khetani, Greg J. Zahner, Melinda S. Schaller, Warren J. Gasper, Nancy K. Hills, Anne L. Schafer, S. Marlene Grenon. PC128. Serum Resistin Is Associated With Impaired Endothelial Function and Poor Outcomes in Patients With Peripheral Artery Disease. . 2018 Jun 1; 67(6):e208-e209. View in PubMed
  34. Gagnon C, Schafer AL. Bone Health After Bariatric Surgery. JBMR Plus. 2018 May; 2(3):121-133. View in PubMed
  35. Chiang JM, Kaysen GA, Schafer AL, Delgado C, Johansen KL. Fibroblast Growth Factor 23 is Associated With Adiposity in Patients Receiving Hemodialysis: Possible Cross Talk Between Bone and Adipose Tissue. J Ren Nutr. 2018 07; 28(4):278-282. View in PubMed
  36. Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women. J Bone Miner Res. 2018 06; 33(6):975-986. View in PubMed
  37. Kim Tiffany Y,Anne L. Schafer. Chapter 64 Bariatric Surgery, Vitamin D, and Bone Loss. . 2018 Jan 1; 129-150. View in PubMed
  38. Kim Tiffany Y, Anne L. Schafer. Chapter 64 Bariatric Surgery, Vitamin D, and Bone Loss. Vitamin D. 2018 Jan 1; 129-150. View in PubMed
  39. Napoli N, Schwartz AV, Schafer AL, Vittinghoff E, Cawthon PM, Parimi N, Orwoll E, Strotmeyer ES, Hoffman AR, Barrett-Connor E, Black DM, Osteoporotic Fractures in Men (MrOS) Study Research Group. Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study. J Bone Miner Res. 2018 01; 33(1):63-69. View in PubMed
  40. Katzman WB, Parimi N, Gladin A, Poltavskiy EA, Schafer AL, Long RK, Fan B, Wong SS, Lane NE. Sex differences in response to targeted kyphosis specific exercise and posture training in community-dwelling older adults: a randomized controlled trial. BMC Musculoskelet Disord. 2017 Dec 04; 18(1):509. View in PubMed
  41. Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL. Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass. J Bone Miner Res. 2017 Nov; 32(11):2239-2247. View in PubMed
  42. Katzman WB, Vittinghoff E, Lin F, Schafer A, Long RK, Wong S, Gladin A, Fan B, Allaire B, Kado DM, Lane NE. Targeted spine strengthening exercise and posture training program to reduce hyperkyphosis in older adults: results from the study of hyperkyphosis, exercise, and function (SHEAF) randomized controlled trial. Osteoporos Int. 2017 10; 28(10):2831-2841. View in PubMed
  43. W.B. Katzman, N. Parimi, A. Schafer, R. Long, S. Wong, N. Lane. SEX DIFFERENCES IN RESPONSE TO A TARGETED KYPHOSIS SPECIFIC EXERCISE PROGRAM. Innovation in Aging. 2017 Jul 1; 1(suppl_1):589-590. View in PubMed
  44. Schafer AL. Vitamin D and intestinal calcium transport after bariatric surgery. J Steroid Biochem Mol Biol. 2017 10; 173:202-210. View in PubMed
  45. Kim TY, Schafer AL. Diabetes and Bone Marrow Adiposity. Curr Osteoporos Rep. 2016 12; 14(6):337-344. View in PubMed
  46. Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S. Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD. Bone Rep. 2016 Dec; 5:312-319. View in PubMed
  47. Napoli N, Schafer AL, Lui LY, Cauley JA, Strotmeyer ES, Le Blanc ES, Hoffman AR, Lee CG, Black DM, Schwartz AV. Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study. Bone. 2016 09; 90:181-4. View in PubMed
  48. Kim TY, Schafer AL. Variability in DXA Reporting and Other Challenges in Osteoporosis Evaluation. JAMA Intern Med. 2016 Mar; 176(3):393-5. View in PubMed
  49. Schafer AL. Decline in Bone Mass During Weight Loss: A Cause for Concern? J Bone Miner Res. 2016 Jan; 31(1):36-9. View in PubMed
  50. Anne L. Schafer. Intestinal Calcium Absorption and Skeletal Health After Bariatric Surgery. Nutritional Influences on Bone Health. 2016 Jan 1; 271-278. View in PubMed
  51. Anne L. Schafer. Intestinal Calcium Absorption and Skeletal Health After Bariatric Surgery. . 2016 Jan 1; 271-278. View in PubMed
  52. Katzman WB, Vittinghoff E, Kado DM, Schafer AL, Wong SS, Gladin A, Lane NE. Study of Hyperkyphosis, Exercise and Function (SHEAF) Protocol of a Randomized Controlled Trial of Multimodal Spine-Strengthening Exercise in Older Adults With Hyperkyphosis. Phys Ther. 2016 Mar; 96(3):371-81. View in PubMed
  53. Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE. Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status. J Bone Miner Res. 2015 Aug; 30(8):1377-85. View in PubMed
  54. Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Bone. 2015 May; 74:140-5. View in PubMed
  55. Wheeler AL, Tien PC, Grunfeld C, Schafer AL. Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review. AIDS. 2015 Jan 14; 29(2):245-6. View in PubMed
  56. Win AZ, Ceresa C, Schafer AL, Mak P, Stewart L. Importance of nutrition visits after gastric bypass surgery for American veterans, San Francisco, 2004-2010. Prev Chronic Dis. 2014 Dec 24; 11:E226. View in PubMed
  57. Lyles CR, Schafer AL, Seligman HK. Income, food insecurity, and osteoporosis among older adults in the 2007-2008 National Health and Nutrition Examination Survey (NHANES). J Health Care Poor Underserved. 2014 Nov; 25(4):1530-41. View in PubMed
  58. Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. J Bone Miner Res. 2014 Apr; 29(4):911-21. View in PubMed
  59. Canales BK, Schafer AL, Shoback DM, Carpenter TO. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Surg Obes Relat Dis. 2014 Sep-Oct; 10(5):878-84. View in PubMed
  60. Schafer AL, Napoli N, Lui L, Schwartz AV, Black DM, Study of Osteoporotic Fractures. Serum 25-hydroxyvitamin D concentration does not independently predict incident diabetes in older women. Diabet Med. 2014 May; 31(5):564-9. View in PubMed
  61. Black DM, Schafer AL. The search for the optimal anabolic osteoporosis therapy. J Bone Miner Res. 2013 Nov; 28(11):2263-5. View in PubMed
  62. Anne L. Schafer,Dolores Shoback. Hypocalcemia: Definition, Etiology, Pathogenesis, Diagnosis, and Management. . 2013 Jul 19; 572-578. View in PubMed
  63. Anne L. Schafer, Dolores Shoback. Hypocalcemia: Definition, Etiology, Pathogenesis, Diagnosis, and Management. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 2013 Jul 19; 572-578. View in PubMed
  64. Schwartz AV, Schafer AL, Grey A, Vittinghoff E, Palermo L, Lui LY, Wallace RB, Cummings SR, Black DM, Bauer DC, Reid IR. Effects of antiresorptive therapies on glucose metabolism: results from the FIT, HORIZON-PFT, and FREEDOM trials. J Bone Miner Res. 2013 Jun; 28(6):1348-54. View in PubMed
  65. Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM. Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS). Osteoporos Int. 2013 Oct; 24(10):2591-601. View in PubMed
  66. Welles CC, Schafer AL, Vittinghoff E, Shlipak MG, Whooley MA, Ix JH. Urine calcium excretion, cardiovascular events, and mortality in outpatients with stable coronary artery disease (from the Heart and Soul study). Am J Cardiol. 2012 Dec 15; 110(12):1729-34. View in PubMed
  67. Schafer AL, Sellmeyer DE, Palermo L, Hietpas J, Eastell R, Shoback DM, Black DM. Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial. J Clin Endocrinol Metab. 2012 Oct; 97(10):3522-9. View in PubMed
  68. Christine C Welles, Anne L Schafer, Eric Vittinghoff, Michael G Shlipak, Mary A Whooley, Joachim H Ix. Abstract P363: Association of Twenty-Four Hour Urine Calcium Excretion with Cardiovascular Events and Mortality: Data from the Heart and Soul Study. Circulation. 2012 Mar 13; 125(suppl_10). View in PubMed
  69. Schafer AL, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM. Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study). J Clin Endocrinol Metab. 2011 Dec; 96(12):E1982-9. View in PubMed
  70. Li X, Kuo D, Schafer AL, Porzig A, Link TM, Black D, Schwartz AV. Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. J Magn Reson Imaging. 2011 Apr; 33(4):974-9. View in PubMed
  71. Schafer AL, Palermo L, Bauer DC, Bilezikian JP, Sellmeyer DE, Black DM. Consistency of bone turnover marker and calcium responses to parathyroid hormone (1-84) therapy in postmenopausal osteoporosis. J Clin Densitom. 2011 Jan-Mar; 14(1):68-73. View in PubMed
  72. Schafer AL, Vittinghoff E, Lang TF, Sellmeyer DE, Harris TB, Kanaya AM, Strotmeyer ES, Cawthon PM, Cummings SR, Tylavsky FA, Scherzinger AL, Schwartz AV, Health, Aging, and Body Composition (Health ABC) Study. Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. J Clin Endocrinol Metab. 2010 Nov; 95(11):E368-72. View in PubMed
  73. Wu AHB, Branch J, Schafer A, Murphy E . Mild positive hCG in a perimenopausal female: normal, malignancy, or phantom?. Lab Medicine. 2009; 40:463-5. View in PubMed
  74. Schafer AL, Vittinghoff E, Ramachandran R, Mahmoudi N, Bauer DC. Laboratory reproducibility of biochemical markers of bone turnover in clinical practice. Osteoporos Int. 2010 Mar; 21(3):439-45. View in PubMed
  75. Schafer AL, Sellmeyer DS. Interventions to improve treatment of osteoporosis following fracture. J Clin Outcomes Manag. 2008; 15:587-94. View in PubMed
  76. Agius MA, Kirvan CA, Schafer AL, Gudipati E, Zhu S. High prevalence of anti-alpha-crystallin antibodies in multiple sclerosis: correlation with severity and activity of disease. Acta Neurol Scand. 1999 Sep; 100(3):139-47. View in PubMed
  77. Agius MA, Zhu S, Kirvan CA, Schafer AL, Lin MY, Fairclough RH, Oger JJ, Aziz T, Aarli JA. Rapsyn antibodies in myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:516-21. View in PubMed